Neonatal Magnetic Resonance Imaging Pattern of Brain Injury as a Biomarker of Childhood Outcomes following a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy
Shankaran, S., McDonald, S. A., Laptook, A. R., Hintz, S. R., Barnes, P. D., Das, A., ... Eunice Kennedy Shriver Natl Inst C (2015). Neonatal Magnetic Resonance Imaging Pattern of Brain Injury as a Biomarker of Childhood Outcomes following a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy. Journal of Pediatrics, 167(5), 987-+. DOI: 10.1016/j.jpeds.2015.08.013, 10.1016/j.jpeds.2015.08.013
Objective To examine the ability of magnetic resonance imaging (MRI) patterns of neonatal brain injury defined by the National Institute of Child Health and Human Development Neonatal Research Network to predict death or IQ at 6-7 years of age following hypothermia for neonatal encephalopathy.
Study design Out of 208 participants, 124 had MRI and primary outcome (death or IQ
Results Death or IQ
Conclusions The Neonatal Research Network MRI pattern of neonatal brain injury is a biomarker of neurodevelopmental outcome at 6-7 years of age.