An improved method for preparation of cocaine receptor bindingligands is provided. The method calls for the preparation of thesilylaryl intermediate prepared from phenyl trimethylsilane and aanhydroecgonine methyl ester appropriately substituted. Theintermediate is prepared in high purity and can be directlyconverted to the binding ligand by iodine substitution.
Method for making cocaine receptor binding ligands and intermediates therefor
Carroll, F. (2000). Method for making cocaine receptor binding ligands and intermediates therefor. (U.S. Patent No. 6123917). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6123917