Changes in the atomic coordinate fluctuations contribute to the entropy of biomolecular processes such as complex formation. Characterizations of such changes in proteins reveal that the response may be dramatically different between the backbone and the side chains, and further resolve enthalpy-entropy compensation at the molecular level.
May the driving force be with you - whatever it is
Cavanagh, J., & Akke, M. (2000). May the driving force be with you - whatever it is. Nature Structural and Molecular Biology, 7(1), 11-13.