• Journal Article

A lower allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer

Citation

Tang, P., Wang, J., Hicks, D. G., Schiffhauer, L., McMahon, L., Yang, Q., ... Lyman, G. (2010). A lower allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer. Cancer Investigation, 28(9), 978-982. DOI: 10.3109/07357907.2010.496754

Abstract

Among the 77 infiltrating breast carcinomas, we found that progesterone receptor (PR) expression was inversely associated with recurrence score (RS, p < .0001). RS is also significantly associated with tubule formation, mitosis, and luminal B subtype. The equation of RS = 17.489 + 2.071 (tubal formation) + 2.926 (mitosis) –2.408 (PR) –1.061 (HER2) + 7.051 (luminal A) + 29.172 (luminal B) predicts RS with an R2 of 0.65. In conclusion, PR negativity, luminal B subtype, tubal formation, and mitosis are strongly correlated with a higher RS.