Formulation screening to achieve performance prediction of pharmaceutical dry powder aerosols
Hickey, A. J., Mansour, H. M., Telko, M., Xu, Z., Mulder, T., McLean, R., ... Papadopoulos, D. (2006). Formulation screening to achieve performance prediction of pharmaceutical dry powder aerosols. In The Aerosol Society Drug Delivery to the Lungs XVII, Scotland, UK, Nov. 30-Dec. 1, , pp. 369–369. .
The performance of dry powder aerosols for the delivery of drugs to the lungs has been studied extensively in the last decade. The focus for different research groups has been on aspects which relate to solid state characterization, surface and interfacial chemistry, bulk properties (static
and dynamic) and measures of aerosol performance. Studies in this field have been complex and correlations between specific properties and performance seem to be rare. Consequently, the adoption of formulation approaches that predictably lead to desirable performance has been an elusive goal but one of great importance for the efficiency and reproducibility of drug delivery from this dosage form. The purpose of this presentation is to share data obtained by a variety of techniques, elucidating various aspects of dry particle behavior, with emphasis on salbutamol in carrier lactose blends, placing them in the context of literature on this subject as a guide to potential screening strategies. A framework constructed with reference to a range of techniques would allow a broad database to be constructed from all available observations that would facilitate the development of predictive models.