Enamine-based aldol organocatalysis in water: Are they really “all wet”?
Reactions with,in, oronwater? Despite claims to the contrary, few examples of truly aqueous organocatalysis have been reported. Close examination of the data from recent reports reveals that these reactions likely occur in concentrated organic phases.
Brogan, A., Dickerson, TJ., & Janda, KD. (2006). Enamine-based aldol organocatalysis in water: Are they really “all wet”? Angewandte Chemie-International Edition, 45(48), 8100-8102. https://doi.org/10.1002/anie.200601392