• Journal Article

Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study

Citation

Morris, B. H., Tyson, J. E., Stevenson, D. K., Oh, W., Phelps, D. L., O'Shea, T. M., ... Higgins, R. D. (2013). Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study. Journal of Perinatology, 33(2), 126-133. DOI: 10.1038/jp.2012.39

Abstract

Objective: Evaluate the efficacy of phototherapy (PT) devices and the outcomes of extremely premature infants treated with those devices. Study Design: This substudy of the National Institute of Child Health and Human Development Neonatal Research Network PT trial included 1404 infants treated with a single type of PT device during the first 24 +/- 12 h of treatment. The absolute (primary outcome) and relative decrease in total serum bilirubin (TSB) and other measures were evaluated. For infants treated with one PT type during the 2-week intervention period (n = 1223), adjusted outcomes at discharge and 18 to 22 months corrected age were determined. Result: In the first 24 h, the adjusted absolute (mean (+/- s.d.)) and relative (%) decrease in TSB (mg dl(-1)) were light-emitting diodes (LEDs) -2.2 (+/- 3), -22%; Spotlights -1.7 (+/- 2), -19%; Banks -1.3 (+/- 3), -8%; Blankets -0.8 (+/- 3), -1%; (P<0.0002), Some findings at 18 to 22 months differed between groups. Conclusion: LEDs achieved the greatest initial absolute reduction in TSB but were similar to Spots in the other performance measures. Long-term effects of PT devices in extremely premature infants deserve rigorous evaluation. Journal of Perinatology (2013) 33, 126-133; doi:10.1038/jp.2012.39; published online 12 April 2012