Effects of time since previous meal and time of day on plasma zinc concentrations in community-based intervention trials: implications for assessing population zinc status
Brown, K. H., Arsenault, J. E., Wuehler, S. E., Lopez de Romana, D., Penny, M. E., & Sempertegui, F. (2007). Effects of time since previous meal and time of day on plasma zinc concentrations in community-based intervention trials: implications for assessing population zinc status. In , pp. A709–A709. .
Measurement of fasting plasma zinc (PZn) concentration (conc) is not feasible for young children in community studies. We assessed the effects of time since last meal and hour of day on morning PZn concs of young children in trials in Peru and Ecuador. Peruvian children (n=297) were initially 6–8 mos of age; PZn concs were measured before and 6 mos after providing daily placebo or 3 mg/d supplemental zinc in either syrup or fortified porridge. Ecuadorian children (n=646) were initially 12–30 mos; only pre-intervention data are analyzed. In the Peru study, children either were allowed to breastfeed 1.5 hrs prior to blood sampling or the time of the last feed was recorded. In both studies the time of blood sampling was noted. In Peru, PZn concs were positively correlated with the number of hrs since the previous meal (r=0.22, p