• Journal Article

Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model

Citation

Carroll, F., Harris, L. S., & Aceto, M. D. (2005). Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model. European Journal of Pharmacology, 524(1-3), 89-94.

Abstract

JDTic, (3R)-7-hydroxy-N-{(IS)-1- [(3R,4R)-4-(3-hydroxyphenyl)-3,4-diniethyl-1-piperidinyl]methyl}-2-methy lpropyl}-1,2,3,4-tetrahydro-3-isoquinoline-carboxamide, is a potent and selective K-opioid antagonist with a very long duration of action [Carroll, F.I., Thomas, J.B., Dykstra, L. A., Granger, A.L., Allen, R.M., Howard, U., Pollard, G.T., Aceto, M.D., Harris, L.S., 2004. Pharmacological properties of JDTic: A novel kopioid receptor antagonist. Eur. J. Pharmacol. 501, 111-119.]. When given 24 h prior to a continuous 4-day infusion of morphine sulfate in rats, JDTic did not prevent the stereotypy that developed during the infusion of morphine. It had no effect on the dramatic loss of body weight associated with the abrupt withdrawal of morphine. However, it decreased the number of important withdrawal signs designated wet-dog shakes and facial rubs. These data suggest that JDTic may find some application in the treatment of opiate abuse. (c) 2005 Elsevier B.V. All rights reserved