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Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying

Luz, I., Stewart, I. E., Mortensen, N. P., & Hickey, A. J. (2020). Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying. Chemical Communications, 56(87), 13339-13342. https://doi.org/10.1039/d0cc05471b

Abstract

Inhalable metal organic framework (MOF) aerosols have been developed via spray drying as a therapy for multi-drug resistant (MDR) tuberculosis (TB). The CuPOA2 (pyrazinoate acid) MOFs can be tailored to exhibit a respirable mass median aerodynamic diameter (MMAD) of 2.6 μm. This method is repeated to manufacture Gd0.1Cu0.9(POA)2 MOFs for inhalable theragnostics.

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