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Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022)

Two new xanthone-anthraquinone heterodimers, acremoxanthone C (5) and acremoxanthone D (2), have been isolated from an extract of an unidentified fungus of the order Hypocreales (MSX 17022) by bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. Two known related compounds, acremonidin A (4) and acremonidin C (3) were also isolated, as was a known benzophenone, moniliphenone (1). The structures of these isolates were determined via extensive use of spectroscopic and spectrometric tools in conjunction with comparisons to the literature. All compounds (1-5) were evaluated against a suite of biological assays, including those for cytotoxicity, inhibition of the 20S proteasome, mitochondrial transmembrane potential and nuclear factor-kappa B. The Journal of Antibiotics (2012) 65, 3-8; doi:10.1038/ja.2011.95; published online 9 November 2011

Citation

Ayers, S., Graf, T. N., Adcock, A. F., Kroll, D. J., Shen, Q., Swanson, S. M., ... Oberlies, N. H. (2012). Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022). Journal of Antibiotics, 65(1), 3-8. DOI: 10.1038/ja.2011.95

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