• Journal Article

Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022)

Citation

Ayers, S., Graf, T. N., Adcock, A. F., Kroll, D. J., Shen, Q., Swanson, S. M., ... Oberlies, N. H. (2012). Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022). Journal of Antibiotics, 65(1), 3-8. DOI: 10.1038/ja.2011.95

Abstract

Two new xanthone-anthraquinone heterodimers, acremoxanthone C (5) and acremoxanthone D (2), have been isolated from an extract of an unidentified fungus of the order Hypocreales (MSX 17022) by bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. Two known related compounds, acremonidin A (4) and acremonidin C (3) were also isolated, as was a known benzophenone, moniliphenone (1). The structures of these isolates were determined via extensive use of spectroscopic and spectrometric tools in conjunction with comparisons to the literature. All compounds (1-5) were evaluated against a suite of biological assays, including those for cytotoxicity, inhibition of the 20S proteasome, mitochondrial transmembrane potential and nuclear factor-kappa B. The Journal of Antibiotics (2012) 65, 3-8; doi:10.1038/ja.2011.95; published online 9 November 2011