A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler
The design, fabrication and characterization of a compact optical biosensor based on an input grating coupler are presented. The sensor device consists of a waveguide-integrated single grating structure. The optical reader is based on the use of a largely tunable, small footprint infrared laser for wavelength interrogation of the sensor and on edge-detection of waveguided modes, resulting in a compact configuration. A multiplexing approach is illustrated and a two-output sensor system is demonstrated. The device is packaged in a microfluidic cartridge for sample handling. The volumetric sensing performance of the system is characterized and a limit of detection of 1 × 10?5 RIU is reported while the surface sensing capability is demonstrated by detection of protein diluted down to 200 ng/ml.
Grego, S., Gilchrist, K., Carlson, J., & Stoner, B. (2012). A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler. Sensors and Actuators B: Chemical, 161(1), 721-727. https://doi.org/10.1016/j.snb.2011.11.020