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Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections

BACKGROUND: Current guidelines for prevention of neonatal group B streptococcal disease recommend diagnostic evaluations and empirical antibiotic therapy for well-appearing, chorioamnionitis-exposed newborns. Some clinicians question these recommendations, citing the decline in early-onset group B streptococcal disease rates since widespread intrapartum antibiotic prophylaxis implementation and potential antibiotic risks. We aimed to determine whether chorioamnionitis-exposed newborns with culture-confirmed, early-onset infections can be asymptomatic at birth. METHODS: Multicenter, prospective surveillance for early-onset neonatal infections was conducted during 2006-2009. Early-onset infection was defined as isolation of a pathogen from blood or cerebrospinal fluid collected


Wortham, JM., Hansen, N., Schrag, SJ., Hale, E., Van, MK., Sanchez, PJ., ... Stoll, BJ. (2016). Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections. Pediatrics, 137(1), 1-11. https://doi.org/10.1542/peds.2015-2323