• Journal Article

Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections

Citation

Wortham, J. M., Hansen, N., Schrag, S. J., Hale, E., Van, M. K., Sanchez, P. J., ... Stoll, B. J. (2016). Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections. Pediatrics, 137(1), 1-11. DOI: 10.1542/peds.2015-2323

Abstract

BACKGROUND: Current guidelines for prevention of neonatal group B streptococcal disease recommend diagnostic evaluations and empirical antibiotic therapy for well-appearing, chorioamnionitis-exposed newborns. Some clinicians question these recommendations, citing the decline in early-onset group B streptococcal disease rates since widespread intrapartum antibiotic prophylaxis implementation and potential antibiotic risks. We aimed to determine whether chorioamnionitis-exposed newborns with culture-confirmed, early-onset infections can be asymptomatic at birth. METHODS: Multicenter, prospective surveillance for early-onset neonatal infections was conducted during 2006-2009. Early-onset infection was defined as isolation of a pathogen from blood or cerebrospinal fluid collected