Azabicyloalkane phenyl substituted alkane carboxylates, their preparation and use as anticholinergic agents

Chiang, P. K., Richard, M. M., Padilla, F. N., Carroll, F., & Abraham, P. (1987). IPC No. U.S.Azabicyloalkane phenyl substituted alkane carboxylates, their preparation and use as anticholinergic agents (Patent No. 4713391.)

This invention relates to novel compositions, their preparationand the use thereof as anticholinergic agents in the treatment orprophylaxis of organophosphate or nerve gas poisoning in animals.These compositions and pharmaceutical preparations containing themin their free base form and acid addition salts thereof arerepresented by the formula ##STR1## wherein R represents loweralkyl groups containing 1 to 7 carbon atoms; R.sup.1 representshydrogen, phenyl, cyclohexyl, and cyclopentyl; and R.sup.2represents lower alkyl groups containing 1 to 7 carbon atoms,hydroxymethyl, and hydroxyl.