• Journal Article

3 alpha-(4-substituted phenyl)nortropane-2 beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter

Citation

Blough, B., Holmquist, C., Abraham, P., Kuhar, M. J., & Carroll, F. (2000). 3 alpha-(4-substituted phenyl)nortropane-2 beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorganic and Medicinal Chemistry Letters, 10(21), 2445-2447.

Abstract

A series of 3 alpha-(4-substituted)nortropane-2 beta -carboxylic acid methyl esters was synthesized and evaluated for the ability to inhibit radioligand binding at the dopamine, serotonin, and norepinephrine transporters. 3 alpha-(4-Methylphenyl)nortropane-2 beta -carboxylic acid methyl ester (4c) was found to be selective and highly potent for the norepinephrine transporter (NET) relative to the dopamine and serotonin transporters. (C) 2000 Elsevier Science Ltd. All rights reserved