17.beta.-nitro-11.beta.-arylisteroids and their derivatives having agonist or antagonist hormonal properties
Cook, C., Kepler, J., Shetty, R. S., Bartley, G. S., & Lee, D. Y. (2000). IPC No. U.S.17.beta.-nitro-11.beta.-arylisteroids and their derivatives having agonist or antagonist hormonal properties (Patent No. 6015805.)
The invention is directed to 11.beta.-arylsteroids of formulaII: ##STR1## wherein R.sup.1, R.sup.6, R.sup.8, R.sup.12 and X areas defined by the specification. The compounds exhibit potentantiprogestational activity and are useful in the treatment offibroids, endometriosis, cervical ripening prior to delivery,hormone replacement therapy and in the control of fertility.