[14C] Chromium picolinate monohydrate: Disposition and metabolism in rats and mice. Project report. RTI Report No. RTI/64U-6855/15P
Chromium picolinate (chromium trispicolinate, chromium tripicolinate, Cr3P) is a synthetic compound that has widespread use as a nutritional supplement. Chromium (Cr) is an essential element to life, being required for proper glucose metabolism and potentiation of the action of insulin. Cr3P is claimed to have enhanced bioavailability of chromium compared with chromium from dietary sources although Gargas et al. reported that the extent of absorption of Cr3P by adult volunteers was still low (2.8 ??1.1%). Although Cr3P toxicity has not been found in in vivo studies, in vitro studies have shown that Cr3P produces chromosomal aberrations in Chinese hamster ovary cells and that Cr3P is reduced by biological reductants in vitro, ultimately leading to the generation of hydroxyl radicals and the cleavage of DNA. The goal of our studies was to determine the disposition of both the chromium and the organic portions of Cr3P in rats and mice to aid in interpretation of prior studies and as an aid in planning any future toxicity studies.