Publications Related to "Allen W. Mangel"

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Clinical Trials in Irritable Bowel Syndrome: A Review

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and it is characterized by episodes of abdominal pain and altered bowel functions. The specific bowel disturbances of diarrhea, constipation or an alternation...

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What should be the primary end point in irritable bowel syndrome?

Irritable bowel syndrome, one of the most common gastrointestinal disorders, is characterized by abdominal pain/discomfort and disturbances in bowel functions. Choosing the correct primary end point in irritable bowel syndrome clinical trials has...

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End points in irritable bowel syndrome

The success of a clinical trial rests on achieving clinical and statistical significance on the primary end point of the study. Therefore, proper selection of primary and key secondary end points is of the utmost importance for obtaining...

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Urgency as an endpoint in irritable bowel syndrome

Background: The choice of endpoints is crucial for proper evaluation of agents in clinical trials of irritable bowel syndrome (IBS). In a recently published draft guidance for IBS from the United States Food and Drug Administration (FDA), urgency...

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Does timing of colon procedures affect outcomes in D-IBS trials?

Background: Sigmoidoscopy/colonoscopy is usually performed prior to enrollment into clinical trials of irritable bowel syndrome (IBS). Two main reasons are to rule out alternative diagnoses and to ensure that colitis is not present. However, the...

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Asimadoline in the treatment of irritable bowel syndrome

Importance of the field: Irritable bowel syndrome (IBS) represents one of the most common gastrointestinal disorders, with the diarrhea-predominant form (D-IBS) representing an area of high unmet medical need. One difficulty in identifying...

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