Publications Related to "Allen W. Mangel"


End points in irritable bowel syndrome

The success of a clinical trial rests on achieving clinical and statistical significance on the primary end point of the study. Therefore, proper selection of primary and key secondary end points is of the utmost importance for obtaining...


Urgency as an endpoint in irritable bowel syndrome

Background: The choice of endpoints is crucial for proper evaluation of agents in clinical trials of irritable bowel syndrome (IBS). In a recently published draft guidance for IBS from the United States Food and Drug Administration (FDA), urgency...