| Article Title: | Preparation of carbon-14 labeled (3R)-7-hydroxy-N-(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl-1,2,3,4-tetrahydroisoquinolinecarboxamide (JDTic) |
| Publication: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Type: | Journal Article |
| Date: | 2008 |
| Authors: | Berrang, B.D., Lewin, A.H., Carroll, F.I. |
| Abstract: | Starting with [14C]-D-tyrosine, carbon-14 labeled JDTic dihydrochloride with specific activity 15 mCi/mol was prepared in 5% radiochemical yield. Separation of the (3R)- and (3S)-diastereomers was carried out via the 3-phenyl-2,3,10,10a-tetrahydro-5H-imidazo[1,5-b]isoquinolin-1-ones formed by reaction with benzaldehyde.
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| Online Resources: | doi:10.1002/jlcr.1560 |
| Full Citation: | Berrang, B.D., Lewin, A.H., & Carroll, F.I. (2008). Preparation of carbon-14 labeled (3R)-7-hydroxy-N-(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl-1,2,3,4-tetrahydroisoquinolinecarboxamide (JDTic). Journal of Labelled Compounds and Radiopharmaceuticals, 51 (14):440-443. |
