| Title: | Cocaine receptor binding ligands |
| Patent No.: | 7189737 |
| Type: | Patent |
| Date: | 2007 |
| Authors: | Kuhar, M.J., Carroll, F.I., Boja, J.W., Lewin, A.H., Abraham, P. |
| Abstract: | A class of binding ligands for cocaine receptors and other
receptors in the brain. Specifically, a novel family of compounds
shows high binding specificity and activity, and, in a radiolabeled
form, can be used to bind to these receptors, for biochemical
assays and imaging techniques. Such imaging is useful for
determining effective doses of new drug candidates in human
populations. In addition, the high specificity, slow onset and long
duration of the action of these compounds at the receptors makes
them particularly well suited for therapeutic uses, for example as
substitute medication for psychostimulant abuse. Some of these
compounds may be useful in treating Parkinson's Disease or
depression, by virtue of their inhibitory properties at monoamine
transporters. |
| Online Resources: | Patent Details (US PTO) |
| Full Citation: | Kuhar, M.J., Carroll, F.I., Boja, J.W., Lewin, A.H., & Abraham, P. (2007). Cocaine receptor binding ligands. U.S. Patent No. 7,189,737. Washington, D.C.: U.S. Patent and Trademark Office |
