Nuclear Magnetic Resonance Spectroscopy

The state-of-the-art chemical sciences laboratories at RTI offer a variety of measurement and analysis technologies critical to environmental, health, and pharmaceutical research. Our drug discovery and research labs use nuclear magnetic resonance (NMR) spectroscopy to

  • Identify new molecules derived from synthesis, from natural products, or from metabolic studies
  • Identify new ligands for receptors using gradient diffusion techniques
  • Study toxicity of drugs and environmental toxins using NMR-based metabolomics and complex mixture analysis

Services 

  • 1H, 13C, and other routine NMR-active nuclei
  • 3H NMR spectra of tritium-labeled samples
  • Multidimensional proton-proton (COSY, NOESY) and proton-heteronuclear (HMQC, HMBC) correlations

Equipment

  • Varian UNITY INOVA-500 spectrometer with broadband, indirect, and tritium-selective probes
  • Bruker Avance DPX-300 spectrometer with an auto-switchable QNP probe capable of measuring 1H, 13C, 19F, and 31P spectra