Chromatography and Ancillary Techniques

RTI uses state-of-the-science, high-resolution systems to support pharmaceutical development (including clinical trials support), pollution assessment, synthesis of new compounds, and a host of other endeavors that require purity determinations or general quantitative analyses.

Our systems are equipped with a wide variety of injectors, detectors, and columns so that virtually any assay problem can be chromatographically approached. All systems are interfaced with data acquisition and processing systems that optimize data reduction and report generation. The systems are used by RTI chemists, engineers, and pharmaceutical and environmental scientists whose breadth of experience in applying chromatography extends to a diverse range of assay problems.

Capabilities

Liquid chromatography (LC)

Analytical (all modes including RP, normal, chiral, GPC, ion exchange), preparative, microbore, biocompatible, multiple detection modes (UV, Vis, PDA, MS, MS/MS, high-resolution MS, EC, fluorescence) (Contact: John Hines)

Ion chromatography (IC)

Anion, cation with UV/conductivity/indirect photometric detection (Contact: Eva Hardison)

Capillary electrophoresis (UV, PDA)

CZE, cIEF, SDS-Page

Gas Chromatography Moisture Assay

Moisture content has a direct bearing on the purity and stability of drugs, pesticides, and other substances. Thus, accurately determining the moisture content, sometimes at very low levels, is important for the development process.

RTI supports large and small pharmaceutical companies, chemical manufacturers, and government programs by providing gas chromatography moisture assay (GCMA) services. Our analytical chemists use this technique to determine moisture content of solids and high-boiling liquids, combining the detection capability to meet lower assay limits of conventional techniques with the specificity of chromatography for materials not compatible with conventional techniques such as Karl Fischer or thermogravimetric analysis.

GCMA is sensitive, precise, and amenable to almost any nonvolatile substance that is thermally stable. It has the powerful advantage of enabling the determination of moisture content under conditions in which techniques such as Karl Fischer are inadequate due to solubility, reactivity, and sample accessibility issues.

RTI's GCMA capabilities support our growing work in support of pharmaceutical development, pesticide registration, and any effort requiring low-level moisture determination.