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Rangan (Ronnie) Maitra

Research Interests

  • Cystic fibrosis and related etiologies
  • Alcohol-induced liver fibrosis
  • Spinal muscular atrophy
  • Cannabinoid receptors and the endocannabinoid system
  • Use of phage-display technology to develop peptide ligands
  • Development of in vitro assays for screening
  • Molecular pharmacology of drug targets, particularly ion-channels and G protein-coupled receptors

Biography

Ronnie Maitra, PhD, conducted doctoral research in the department of Pharmacology & Toxicology at Dartmouth College. His studies were focused on understanding the mechanisms of chemotherapy-induced differential regulation of ABC transporters CFTR and P-glycoprotein. Dr. Maitra received post-doctoral training under Dr. Ira Pastan in the Laboratory of Molecular Biology at the National Cancer Institute in the area of genomics-driven cancer immunotherapy. Before joining RTI International in the summer of 2005, Dr. Maitra was employed at Paradigm Genetics as the group leader of Experimental Biology where research focused on the discovery of predictive disease-related biomarkers using a systems biology approach. Presently, as a principal investigator on projects funded by NINDS, NIAAA, and biotechnology companies, Dr. Maitra is conducting research related to cystic fibrosis, spinal muscular atrophy, and alcohol-induced liver fibrosis at RTI.

Education

Postdoctoral Fellowship, National Cancer Institute, Laboratory of Molecular Biology, NIH; PhD, Pharmacology & Toxicology, Dartmouth Medical School; BS, Chemistry (cum laude), Angelo State University

Selected Publications

Maitra, R., & Hamilton, J. (Apr 2007). Altered Biogenesis of DeltaF508-CFTR Following Treatment with Doxorubicin. Cellular Physiology and Biochemistry, 20 (5):465-472.
Maitra, R., & Hamilton, J. (2005). Arsenite regulates cystic fibrosis transmem­brane conductance regulator and P-glycoprotein: Evidence of pathway independence. Cellular Physiology and Biochemistry, 16 (1-3):109-118.
Bera, T.K., Maitra, R., Iavarone, C., Salvatore, G., Kumar, V., Vincent, J.J., Sathyanarayana, B.K., Durray, P., Lee, B.K., & Pastan, I. (2002). PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach. Proceedings of the National Academy of Sciences of the United States of America, 99 (5):3058-3063.
Maitra, R., Halpin, P.A., Karlson, K.H., Page, R.L., Paik, D.Y., Leavitt, M.O., Moyer, B.D., Stanton, B.A., & Hamilton, J.W. (2001). Differential effects of mitomycin C and doxorubicin on P-glycoprotein expression. Biochemical Journal, 355 (3):617-624.
Maitra, R., Shaw, C.M., Stanton, B.A., & Hamilton, J.W. (2001). Increased functional cell surface expression of CFTR and F508-CFTR by the anthracycline doxorubicin. American Journal of Physiology - Cell Physiology, 280 (5):C1031-C1037.

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