Brian Gilmour
Biography
Dr. Gilmour came to RTI in 2004 after working at Cogent Neurosciences Inc., an early stage drug discovery company. While at Cogent, he established their molecular biology capabilities and optimized and validated multiple high-throughput biological assays as director of neurogenomics. At RTI, he manages the molecular biology and assay development group. While providing the resources and expertise to perform and interpret cell-based assays, this group is involved in designing, developing, and validating additional assays. Their current focus is on screening and characterization assays for ligands of GPCRs and ion channels. The techniques they use include radioligand-binding assays, FLIPR-based calcium and membrane potential assays, GTP exchange assays, and high-content automated fluorescence imaging.
Education
PhD, Biochemistry, Dartmouth Medical School; BS, Biology, Furman University
Selected Publications
Smith, E.D., Ariane, V.N., Zhong, D., Berrang, B.D., Catanzaro, J.L., Thomas, J.B., Navarro, H.A., Gilmour, B.P., Deschamps, J., & Carroll, F.I. (2008 Jan 15). A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro- 2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay. Bioorganic and Medicinal Chemistry, 16 (2):822-829.
Carroll, F.I., Kotturi, S.V., Navarro, H.A., Mascarella, S.W., Gilmour, B.P., Smith, F.L., Gabra, B.H., & Dewey, W.L. (Jul 2007). Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. Journal of Medicinal Chemistry, 50 (14):3388-3391.
Navarro, H.A., Gilmour, B.P., & Lewin, A.H. (2006). A rapid functional assay for the human trace amine-associated receptor 1 based on the mobilization of internal calcium. Journal of Biomolecular Screening , 11 (6):688-693.
Gilmour, B.P., Goldman, D., Chahine, K.G., & Gardner, P.D. (1995). Electrical activity suppresses nicotinic acetylcholine receptor ? subunit promoter activity. Developmental Biology, 168 (2):416-428.
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