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Anita H. Lewin

Research Interests

  • Structure-activity correlations of bioactive compounds
  • Design and synthesis of labeled compounds
  • Carbon nanoparticles

Biography

Anita H. Lewin, PhD, has broad experience in synthetic organic chemistry, including the synthesis of isotopically (mass- and radio-) labeled compounds, organometallic chemistry, medicinal chemistry, physical-organic chemistry, and in the chemistry of carbon nanoparticles. Since joining RTI International in 1974, Dr. Lewin has been involved in research on CNS-active compounds and their metabolites. She is principal investigator on a grant involving trace amine-associated receptors, and co-principal investigator on two contracts (NIDA, NIMH) aimed at the synthesis and distribution of CNS-active compounds. Both these programs involve the preparation of compounds labeled with tritium and carbon-14 with specific activities of 0.1–200 Ci/mmol. She is also principal investigator on an NCI-sponsored program to prepare and supply radiolabeled compounds to investigators. In addition, Dr. Lewin has prepared radiolabeled components of cosmetics (for FDA), radiolabeled environmental pollutants (for EPA and NIEHS) and, most recently, carbon-14-labeled nanoparticlels (for EPA-sponsored research).

Education

PhD, Physical-Organic Chemistry, University of California, Los Angeles; BSc, Chemistry, University of California, Los Angeles

Selected Publications

Jin, C., Mayer, L.D., Lewin, A.H., Rehder, K.S., & Brine, G.A. (Jan 2008). Practical synthesis of p-aminophenethylspiperone (NAPS), a high-affinity, selective D-2-dopamine receptor antagonist. Synthetic Communications, 38 (5):816-823.
Lewin, A., Jeffcoat, R., & Berrang, B. (2007). Synthesis of carbon-14 labeled dibutyltin dichloride. Journal of Labelled Compounds and Radiopharmaceuticals, 50 (3-4):171-175.
Reddy, P.A., Lewin, A.H., & Carroll, F.I. (Jan 2007). Improved procedure for the synthesis of DAMGO. Synthetic Communications, 37 (14):2345-2348.
Lewin, A.H., Szewczyk, J., Wilson, J.W., & Carroll, F.I. (2005). Galanthamine analogs: 6H-benzofuro[3a,3,2,-e,f][1]benzazepine and 6H-benzofuro[3a,3,2-e,f][3]benzazepine. Tetrahedron, 61 (30):7144-7152.
Wagner, J.M., McElhinny, C.J., Lewin, A.H., & Carroll, F.I. (2003). Stereospecific synthesis of amphetamines. Tetrahedron-Asymmetry, 14 (15):2119-2125.

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