Biostatistics

Biostatistics involves the development and application of methods for quantitative analyses that can derive useful information from data collected in the health sciences. We have been active in collaborative research in the health sciences for more than 30 years and our capabilities in biostatistics cover a broad array of modern methods in the statistical design, conduct, monitoring, data analyses and reporting of studies related to human health. These studies span the gamut of public health research, including randomized clinical trials, long-standing registries, and longitudinal and other observational studies on the epidemiology of human diseases.

We synthesize existing literature to assess the feasibility of conducting trials and studies on various topics of interest. Our biostatisticians also play a crucial role in reviewing proposed studies by providing key input on their methodological soundness. We help set the research direction for various collaborative research groups in helping target resources towards studies that are scientifically sound and have the greatest potential for making a positive impact on human health.

Focus Areas

  • Complex, multisite studies
  • Interdisciplinary studies with multiple data types
  • Randomized clinical trials
  • Disease surveillance
  • Prospective cohort studies
  • Population genetics studies

Methodologies/Techniques

  • Stratified individual and cluster randomization
  • Group sequential monitoring of clinical trials
  • Spatio-temporal data analysis
  • Longitudinal and repeated measures data analysis
  • Hierarchical multilevel modeling
  • Statistical genetics

Capabilities

  • Study design
  • Interim monitoring for safety and efficacy in clinical trials
  • Statistical analyses for various types of health studies
  • Writing statistical sections of peer reviewed journal papers and reports

Projects

  • Data Coordinating Center for the NICHD Neonatal Research Network. RTI provides statistical leadership to this multisite clinical research network, designing and analyzing various types of multiphase randomized clinical trials and observational studies, long-standing registries, and longitudinal studies of children and their caregivers.
  • Technical Support for the Pregnancy Risk Assessment Monitoring System (PRAMS). Support for surveillance activities to monitor self reported maternal attitudes and behaviors before, during, and after pregnancy.
  • Population Genetics Analysis Program: Immunity in Response to Typhoid/Cholera Vaccines. RTI conducts collaborative research on innate and adaptive immunity genes associated with response to typhoid and cholera vaccines and the consequent protein expression.
Spotlight

RTI International Joins Effort to Study Traumatic Brain Injuries, Concussions in Military Personnel, Veterans

As part of a federal initiative to better understand traumatic brain injuries suffered by the nation’s military service members and veterans, researchers at RTI International will join a consortium led by Virginia Commonwealth University to better understand the long-term effects of chronic mild brain injuries, or concussions. Read more