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Tim Fennell
919-485-2781

Timothy R. Fennell

Director, Pharmacology and Toxicology

Timothy Fennell, PhD, conducts in vitro and in vivo research investigations funded by industrial, commercial, and government clients. He has more than 30 years of experience in mechanistic-based research and is recognized as an expert in biomarkers, particularly in the area of reactive chemicals/metabolites and exposure assessment via protein- and DNA-adduct measurement. His recent research activities in pharmacology include investigations of the pharmacokinetics of potential therapeutic agents and their ability to cross the blood-brain barrier. Dr. Fennell serves as the director of the RTI Center for Nanotechnology Health Implications Research funded by the National Institute of Environmental Health Sciences. Projects in this Center develop lab-based data for cells and rodents exposed to nanoparticles for the construction and validation of physiologically based pharmacokinetic models to provide a firm basis for the informed assessment of health risks associated with exposure to nanoparticles.

Education

PhD, Biochemistry, Department of Biochemistry, University of Surrey, Great Britain; BSc, Biochemistry (Honors), Department of Biochemistry, University of Surrey.

Latest Publications

Metabolism and disposition of [(14)C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application — Xenobiotica
Mathews, J.M., Brown, S.S., Patel, P.R., Black, S.R., Banks, T.T., Etheridge, A.S., Fennell, T.R., Snyder, R.W., et al. (Feb 2013)
Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice — Xenobiotica
Mathews, J.M., Zhan, Q., Etheridge, A.S., Patel, P.R., Black, S.R., Banks, T.T., Fennell, T.R., Snyder, R.W., Burgess, J.P., et al. (Dec 2012)
Multi-walled carbon nanotube directed gene and protein expression in cultured human aortic endothelial cells is influenced by suspension medium — Toxicology
Vidanapathirana, A.K., Lai, X.Y., Hilderbrand, S.C., Pitzer, J.E., Podila, R., Sumner, S.J., Fennell, T.R., et al. (Dec 2012)
Diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 antagonists — Journal of Medicinal Chemistry
Fulp, A., Bortoff, K., Zhang, Y., Seltzman, H., Mathews, J., Snyder, R., Fennell, T., & Maitra, R. (Nov 2012)
Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity — Journal of Medicinal Chemistry
Fulp, A., Bortoff, K., Seltzman, H., Zhang, Y., Mathews, J., Snyder, R., Fennell, T., & Maitra, R. (Mar 2012)
View all publications by Timothy R. Fennell

Expertise