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919-485-2781

Timothy R. Fennell

Director, Pharmacology and Toxicology

Timothy Fennell, PhD, conducts in vitro and in vivo research investigations funded by industrial, commercial, and government clients. He has more than 30 years of experience in mechanistic-based research and is recognized as an expert in biomarkers, particularly in the area of reactive chemicals/metabolites and exposure assessment via protein- and DNA-adduct measurement. His recent research activities in pharmacology include investigations of the pharmacokinetics of potential therapeutic agents and their ability to cross the blood-brain barrier. Dr. Fennell serves as the director of the RTI Center for Nanotechnology Health Implications Research funded by the National Institute of Environmental Health Sciences. Projects in this Center develop lab-based data for cells and rodents exposed to nanoparticles for the construction and validation of physiologically based pharmacokinetic models to provide a firm basis for the informed assessment of health risks associated with exposure to nanoparticles.

Education

PhD, Biochemistry, Department of Biochemistry, University of Surrey, Great Britain; BSc, Biochemistry (Honors), Department of Biochemistry, University of Surrey.

Latest Publications

Thompson, L.C., Urankar, R.N., Holland, N.A., Vidanapathirana, A.K., Pitzer, J.E., Han, L., Sumner, S.J., Lewin, A.H., Fennell, T.R., et al. (2014). C-60 Exposure Augments Cardiac Ischemia/Reperfusion Injury and Coronary Artery Contraction in Sprague Dawley Rats. Toxicological Sciences, 138 (2):365-378.
Brisson, B., Ayotte, P., Normandin, L., Gaudreau, E., Bienvenu, J.F., Fennell, T.R., Blanchet, C., Phaneuf, D., Lapointe, C., Bonvalot, Y., Gagne, M., Courteau, M., Snyder, R.W., et al. (2014). Relation between dietary acrylamide exposure and biomarkers of internal dose in Canadian teenagers. Journal of Exposure Science & Environmental Epidemiology, 24 (2):215-221.
Banks, M.L., Blough, B.E., Fennell, T.R., Snyder, R.W., & Negus, S.S. (2013). Effects of Phendimetrazine Treatment on Cocaine vs Food Choice and Extended-Access Cocaine Consumption in Rhesus Monkeys. Neuropsychopharmacology, 38 (13):2698-2707.
Phelps, D.L., Ward, R.M., Williams, R.L., Watterberg, K.L., Laptook, A.R., Wrage, L.A., Nolen, T.L., Fennell, T.R., Ehrenkranz, R.A., Poindexter, B.B., Cotten, C.M., Hallman, M.K., Frantz, I.D., Faix, R.G., Zaterka-Baxter, K.M., Das, A., et al. (2013). Pharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23-29 wk. Pediatric Research, 74 (6):721-729.
Fulp, A., Bortoff, K., Zhang, Y., Snyder, R., Fennell, T., Marusich, J.A., Wiley, J.L., Seltzman, H., & Maitra, R. (2013). Peripherally Selective Diphenyl Purine Antagonist of the CB1 Receptor. Journal of Medicinal Chemistry, 56 (20):8066-8072.
View all publications by Timothy R. Fennell (82)