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919-485-2781

Timothy R. Fennell

Director, Pharmacology and Toxicology

Timothy Fennell, PhD, conducts in vitro and in vivo research investigations funded by industrial, commercial, and government clients. He has more than 30 years of experience in mechanistic-based research and is recognized as an expert in biomarkers, particularly in the area of reactive chemicals/metabolites and exposure assessment via protein- and DNA-adduct measurement. His recent research activities in pharmacology include investigations of the pharmacokinetics of potential therapeutic agents and their ability to cross the blood-brain barrier. Dr. Fennell serves as the director of the RTI Center for Nanotechnology Health Implications Research funded by the National Institute of Environmental Health Sciences. Projects in this Center develop lab-based data for cells and rodents exposed to nanoparticles for the construction and validation of physiologically based pharmacokinetic models to provide a firm basis for the informed assessment of health risks associated with exposure to nanoparticles.

Education

PhD, Biochemistry, Department of Biochemistry, University of Surrey, Great Britain; BSc, Biochemistry (Honors), Department of Biochemistry, University of Surrey.

Latest Publications

Sumner, S.C., Snyder, R.W., Wingard, C., Mortensen, N.P., Holland, N.A., Shannahan, J.H., Dhungana, S., Pathmasiri, W., Han, L., Lewin, A.H., & Fennell, T.R. (2015). Distribution and biomarkers of carbon-14-labeled fullerene C60([14C(U)]C60) in female rats and mice for up to 30 days after intravenous exposure. Journal of Applied Toxicology, Advance Online Publication .
Poitras, E.P., Levine, M.A., Harrington, J.M., Essader, A.S., Fennell, T.R., Snyder, R.W., Black, S.L., Sumner, S.S., & Levine, K.E. (2015). Development of an Analytical Method for Assessment of Silver Nanoparticle Content in Biological Matrices by Inductively Coupled Plasma Mass Spectrometry. Biological Trace Element Research, 163 (1-2):184-192.
Fennell, T.R., Morgan, D.L., Watson, S.L., Dhungana, S., & Waidyanatha, S. (2015). Systemic uptake, albumin and hemoglobin binding of [14C]2,3-butanedione administered by intratracheal instillation in male Harlan Sprague Dawley rats and oropharyngeal aspiration in male B6C3F/N mice. Chemico-Biological Interactions, 227 :112-119.
Vidanapathirana, A.K., Thompson, L.C., Mann, E.E., Odom, J.T., Holland, N.A., Sumner, S.J., Han, L., Lewin, A.H., Fennell, T.R., et al. (2014). PVP formulated Fullerene (C60) increases Rho-kinase dependent Vascular Tissue Contractility in Pregnant Sprague Dawley Rats. Reproductive Toxicology, 49 :86-100.
Waidyanatha, S., Gaudette, N.F., Hong, Y., & Fennell, T.R. (2014). Formation of Epichlorohydrin, a Known Rodent Carcinogen, Following Oral Administration of 1,3-Dichloro-2-propanol in Rats. Chemical Research in Toxicology, 27 (10):1787-1795.
View all publications by Timothy R. Fennell (89)

Expertise

  • Biomarkers
  • Exposure Assessment
  • Pharmacokinetics
  • Nanotoxicology