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Timothy R. Fennell

Director, Pharmacology and Toxicology

Timothy Fennell, PhD, conducts in vitro and in vivo research investigations funded by industrial, commercial, and government clients. He has more than 30 years of experience in mechanistic-based research and is recognized as an expert in biomarkers, particularly in the area of reactive chemicals/metabolites and exposure assessment via protein- and DNA-adduct measurement. His recent research activities in pharmacology include investigations of the pharmacokinetics of potential therapeutic agents and their ability to cross the blood-brain barrier. Dr. Fennell serves as the director of the RTI Center for Nanotechnology Health Implications Research funded by the National Institute of Environmental Health Sciences. Projects in this Center develop lab-based data for cells and rodents exposed to nanoparticles for the construction and validation of physiologically based pharmacokinetic models to provide a firm basis for the informed assessment of health risks associated with exposure to nanoparticles.


PhD, Biochemistry, Department of Biochemistry, University of Surrey, Great Britain; BSc, Biochemistry (Honors), Department of Biochemistry, University of Surrey.

Latest Publications

Relation between dietary acrylamide exposure and biomarkers of internal dose in Canadian teenagers — Journal of Exposure Science & Environmental Epidemiology
Brisson, B., Ayotte, P., Normandin, L., Gaudreau, E., Bienvenu, J.F., Fennell, T.R., Blanchet, C., Phaneuf, D., Lapointe, C., Bonvalot, Y., Gagne, M., Courteau, M., Snyder, R.W., et al. (Mar 2014)
Effects of Phendimetrazine Treatment on Cocaine vs Food Choice and Extended-Access Cocaine Consumption in Rhesus Monkeys — Neuropsychopharmacology
Banks, M.L., Blough, B.E., Fennell, T.R., Snyder, R.W., & Negus, S.S. (Dec 2013)
Pharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23-29 wk — Pediatric Research
Phelps, D.L., Ward, R.M., Williams, R.L., Watterberg, K.L., Laptook, A.R., Wrage, L.A., Nolen, T.L., Fennell, T.R., Ehrenkranz, R.A., Poindexter, B.B., Cotten, C.M., Hallman, M.K., Frantz, I.D., Faix, R.G., Zaterka-Baxter, K.M., Das, A., et al. (Dec 2013)
Peripherally Selective Diphenyl Purine Antagonist of the CB1 Receptor — Journal of Medicinal Chemistry
Fulp, A., Bortoff, K., Zhang, Y., Snyder, R., Fennell, T., Marusich, J.A., Wiley, J.L., Seltzman, H., & Maitra, R. (Sep 2013)
Role of phenmetrazine as an active metabolite of phendimetrazine: Evidence from studies of drug discrimination and pharmacokinetics in rhesus monkeys — Drug and Alcohol Dependence
Banks, M.L., Blough, B.E., Fennell, T.R., Snyder, R.W., & Negus, S.S. (Jun 2013)
View all publications by Timothy R. Fennell (81)