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James M. Mathews

Director, Drug Metabolism and Pharmacokinetics

James Mathews, PhD, has more than 25 years of experience directing investigations of the metabolism and disposition of drugs, commodity chemicals, and crop protection products for industry and government. In 1985, Dr. Mathews joined RTI to direct ADME investigations of xenobiotics in mammals. He developed a full-service DMPK department that conducts studies at the molecular and biochemical through cellular and subcellular levels, and with isolated organs and in vivo models. He is the principal investigator (PI) on the NTP project “Chemical Disposition in Mammals” examining the toxic action of chemicals. Dr. Mathews is also the PI on work for the National Institute of Neurological Disorders and Stroke to screen drugs for treatment of spinal muscular atrophy, and he writes expert dossiers on drugs proposed for the treatment of Parkinson Disease. He has authored more than 40 peer-reviewed journal articles, is a diplomate of the American Board of Toxicology, and serves on the executive committee of the Research Triangle Park Drug Metabolism Discussion Group. Dr. Mathews has an adjunct faculty appointment with the School of Pharmacy at the University of North Carolina, Chapel Hill.

Education

PhD, Pharmaceutical Chemistry, University of California, San Francisco; BS, Chemistry, California State University, Northridge.

Latest Publications

Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice — Regulatory Toxicology and Pharmacology
Minnema, D.J., Travis, K.Z., Breckenridge, C.B., Sturgess, N.C., Butt, M., Wolf, J.C., Zadory, D., Beck, M.J., Mathews, J.M., et al. (Mar 2014)
Metabolism and disposition of [C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application — Xenobiotica
Mathews, J.M., Watson, S.L., Patel, P.R., Black, S.R., Hong, Y., Levine, K.E., Ross, G., Germolec, D.R., Thakur, S.A., et al. (Jan 2014)
Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice — Neurotoxicology
Breckenridge, C.B., Sturgess, N.C., Butt, M., Wolf, J.C., Zadory, D., Beck, M., Mathews, J.M., et al. (Jul 2013)
Metabolism and disposition of [(14)C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application — Xenobiotica
Mathews, J.M., Brown, S.S., Patel, P.R., Black, S.R., Banks, T.T., Etheridge, A.S., Fennell, T.R., Snyder, R.W., et al. (Feb 2013)
Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice — Xenobiotica
Mathews, J.M., Zhan, Q., Etheridge, A.S., Patel, P.R., Black, S.R., Banks, T.T., Fennell, T.R., Snyder, R.W., Burgess, J.P., et al. (Dec 2012)
View all publications by James M. Mathews (37)

Expertise