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Allen W. Mangel

Executive Vice President, RTI Health Solutions

Allen Mangel, MD, PhD, is a gastroenterologist and executive vice president of RTI Health Solutions. After his medical training, Dr. Mangel was an intern and resident in internal medicine at Duke University Medical Center and also completed his gastroenterology fellowship at Duke. After this formal training, he remained on the Duke faculty in the Department of Medicine, Division of Gastroenterology. After leaving Duke, he joined the gastroenterology clinical research department at Glaxo Wellcome, where he was head of the gastroenterology clinical development group. Following Glaxo, Dr. Mangel became vice president of research and development at Salix Pharmaceuticals. Dr. Mangel also has a PhD from the University of Illinois, where his research focused on control of electrical and mechanical activity in gastrointestinal smooth muscle. He has led or participated in numerous FDA interactions, advisory committee presentations, label negotiations, and NDA submissions, and he has written over 85 publications.


MD, Georgetown University School of Medicine; PhD, Physiology, University of Illinois; MS, Physiology, University of Illinois; BS, Physiology, University of Illinois.

Latest Publications

Clinical Trials in Irritable Bowel Syndrome: A Review — Rev Recent Clin Trials
Ervin, C.M., & Mangel, A.W. (Mar 2013)
What should be the primary end point in irritable bowel syndrome? — Clinical Investigation
Mangel, A.W. (Feb 2013)
Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: A review — Clinical and Experimental Gastroenterology
Mangel, A.W., & Hicks, G.A. (Jan 2012)
End points in irritable bowel syndrome — Expert Review of Gastroenterology & Hepatology
Mangel, A.W., & Fehnel, S.E. (Jun 2011)
Urgency as an endpoint in irritable bowel syndrome — Gastroenterology Research
Mangel, A.W., Wang, J., Sherrill, B., Gnanasakthy, A., Ervin, C., & Fehnel, S.E. (Feb 2011)
View all publications by Allen W. Mangel (43)