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Brian F. Thomas

Principal Scientist, Analytical Chemistry and Pharmaceutics

Brian F. Thomas, PhD, has more than 20 years of experience in analytical chemistry and mass spectrometry (MS). He is the principal investigator/co-principal investigator on two National Institute on Drug Abuse repository and purity specification contracts. He also holds an R01 grant with the National Institutes of Health. His principal duties include overseeing the development of chromatographic assays (gas chromatography [GC], high-performance liquid chromatography [HPLC], GC/MS, HPLC/MS) and spectrophotometric assays for the qualitative and quantitative analysis of bulk chemicals or chemicals in dosage formulations, biological fluids, tissues, or other complex matrices. Dr. Thomas was recently awarded RTI’s President’s Award for his scientific contributions to the institute.


PhD, Pharmacology, Virginia Commonwealth University; BA, Biology, Kenyon College.

Latest Publications

Nguyen, T., German, N., Decker, A.M., Li, J.X., Wiley, J.L., Thomas, B.F., Kenakin, T.P., & Zhang, Y. (2015). Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators. Bioorganic and Medicinal Chemistry, 23 (9):2195-2203.
Wiley, J.L., Marusich, J.A., Thomas, B.F., & Jackson, K.J. (2015). Determination of behaviorally effective tobacco constituent doses in rats. Nicotine and Tobacco Research, 17 (3):368-371.
Perrey, D.A., German, N.A., Decker, A.M., Thorn, D., Li, J.X., Gilmour, B.P., Thomas, B.F., Harris, D.L., Runyon, S.P., & Zhang, Y. (2015). Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor. ACS Chemical Neuroscience, Advance Online Publication .
Schaich, C.L., Shaltout, H.A., Grabenauer, M., Thomas, B.F., Gallagher, P.E., Howlett, A.C., et al. (2015). Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. J Cardiovasc Pharmacol , Advance Online Publication .
German, N., Decker, A.M., Gilmour, B.P., Gay, E.A., Wiley, J.L., Thomas, B.F., & Zhang, Y. (2014). Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure-Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). Journal of Medicinal Chemistry, 57 (18):7758-7769.
View all publications by Brian F. Thomas (92)


  • Pharmacology
  • Analytical Chemistry
  • Medicinal Chemistry
  • Mass Spectrometry