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Brian F. Thomas

Principal Scientist, Analytical Chemistry and Pharmaceutics

Brian F. Thomas, PhD, has more than 20 years of experience in analytical chemistry and mass spectrometry (MS). He is the principal investigator/co-principal investigator on two National Institute on Drug Abuse repository and purity specification contracts. He also holds an R01 grant with the National Institutes of Health. His principal duties include overseeing the development of chromatographic assays (gas chromatography [GC], high-performance liquid chromatography [HPLC], GC/MS, HPLC/MS) and spectrophotometric assays for the qualitative and quantitative analysis of bulk chemicals or chemicals in dosage formulations, biological fluids, tissues, or other complex matrices. Dr. Thomas was recently awarded RTI’s President’s Award for his scientific contributions to the institute.


PhD, Pharmacology, Virginia Commonwealth University; BA, Biology, Kenyon College.

Latest Publications

Wiley, J.L., Marusich, J.A., Lefever, T.W., Antonazzo, K.R., Wallgren, M.T., Cortes, R.A., Patel, P.R., Grabenauer, M., Moore, K.N., & Thomas, B.F. (2015). AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and potency of novel synthetic cannabinoids in producing delta9-tetrahydrocannabinol-like effects in mice. Journal of Pharmacology and Experimental Therapeutics, 354 (3):328-339.
Perrey, D.A., Decker, A.M., Li, J.X., Gilmour, B.P., Thomas, B.F., Harris, D.L., Runyon, S.P., & Zhang, Y. (2015). The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. Bioorganic and Medicinal Chemistry, 23 (17):5709-5724.
Schaich, C.L., Shaltout, H.A., Grabenauer, M., Thomas, B.F., Gallagher, P.E., Howlett, A.C., et al. (2015). Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. J Cardiovasc Pharmacol , 65 (5):473-479.
Nguyen, T., German, N., Decker, A.M., Li, J.X., Wiley, J.L., Thomas, B.F., Kenakin, T.P., & Zhang, Y. (2015). Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators. Bioorganic and Medicinal Chemistry, 23 (9):2195-2203.
Perrey, D.A., German, N.A., Decker, A.M., Thorn, D., Li, J.X., Gilmour, B.P., Thomas, B.F., Harris, D.L., Runyon, S.P., & Zhang, Y. (2015). Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor. ACS Chemical Neuroscience, 6 (4):599-614.
View all publications by Brian F. Thomas (94)


  • Pharmacology
  • Analytical Chemistry
  • Medicinal Chemistry
  • Mass Spectrometry