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F. Ivy Carroll
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F. Ivy Carroll

Distinguished Fellow, Medicinal Chemistry

F. Ivy Carroll, PhD, is an internationally renowned medicinal chemist who joined RTI in 1960. He served as director of the Center for Organic and Medicinal Chemistry (1975-2007) and research vice president of the Chemistry and Life Sciences Group (1996-2001). Dr. Carroll has made major scientific contributions in drug discovery and development and other research areas. Among his most recognized scientific contributions is the development of a diagnostic agent for Parkinson's disease and compounds as potential treatments for cocaine and nicotine addictions and other central nervous system disorders. He has published more than 459 peer-reviewed publications, 33 book chapters, 45 patents, and several current patent applications. Dr. Carroll has received numerous awards for his research accomplishments, such as the 1993 Pacesetter Award, National Institute on Drug Abuse; the 1993 Distinguished Speaker Award, North Carolina Section of American Chemical Society; the 2000 Southern Chemist Award, Memphis Section of American Chemical Society; the 2001 Charles H. Herty Medal, Georgia Section of American Chemical Society; the 2001 Margaret E. Knox Excellence Award, Research Triangle Institute; the 2002 Division of Medicinal Chemistry Award, American Chemical Society; the 2006 Nathan B. Eddy Award from the College on Problems of Drug Dependence; the 2006 Research Achievement Award in Drug Design and Discovery from the American Association of Pharmaceutical Scientists; the 2010 North Carolina Award for Science; the 2010 National Institute on Drug Abuse Public Service Award for Significant Achievement; the 2012 International Narcotics Research Conference Founder's Lecture Award; and the 2012 American Chemical Society Alfred Burger Award in Medicinal Chemistry. In 2007, he was inducted into the American Chemical Society Medicinal Chemistry Hall of Fame.

Education

PhD, Chemistry, University of North Carolina at Chapel Hill; BS, Chemistry, Auburn University.

Latest Publications

Discovery of N-{4-[(3-Hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybe nzamide Analogues as Selective Kappa Opioid Receptor Antagonists — Journal of Medicinal Chemistry
Kormos, C.M., Jin, C., Cueva, J.P., Runyon, S.P., Thomas, J.B., Brieaddy, L.E., Mascarella, S.W., Navarro, H.A., Gilmour, B.P., & Carroll, F.I. (May 2013)
Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice — Psychopharmacology
Jackson, K.J., McLaughlin, J.P., Carroll, F.I., & Damaj, M.I. (Apr 2013)
Development of kappa opioid receptor antagonists — Journal of Medicinal Chemistry
Carroll, F.I., & Carlezon, W.A. (Mar 2013)
Effects of Monoamine Reuptake Inhibitors in Assays of Acute Pain-Stimulated and Pain-Depressed Behavior in Rats — The journal of Pain
Rosenberg, M.B., Carroll, F.I., & Negus, S.S. (Mar 2013)
Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models — Neuropharmacology
Freitas, K., Ghosh, S., Carroll, F.I., Lichtman, A.H., & Damaj, M.I. (Feb 2013)
View all publications by F. Ivy Carroll

Expertise

  • Medicinal Chemistry
  • Biochemical Addiction
  • Drug Abuse Research

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