Timothy R. Fennell

Expertise

Biomarkers
Exposure Assessment
Pharmacokinetics

Biography

Timothy Fennell, PhD, has more than 25 years of experience in mechanistic-based research, specializing in the areas of metabolism and reactive metabolites. He has served as a principal investigator and GLP (good laboratory practices) study director, conducting studies to evaluate pharmacokinetics, ADME (absorption, distribution, metabolism, and excretion), and toxicity of compounds. The focus of his research has been on the detection and characterization of metabolites, metabolic processes, and their involvement in toxicity. Dr. Fennell is recognized as an expert in biomarkers, particularly in the area of reactive chemicals/metabolites and exposure assessment via protein- and DNA-adduct measurement. He has extensive experience in the isolation and characterization of metabolites and adducts by NMR spectroscopy and mass spectroscopy, and is a leading authority on the metabolism and exposure assessment of acrylamide.

Education

PhD, Biochemistry, Department of Biochemistry, University of Surrey, Great Britain; BSc, Biochemistry (Honors), Department of Biochemistry, University of Surrey.

Selected Publications

Fennell, T.R., Sumner, S.C., Snyder, R.W., Burgess, J., & Friedman, M.A. (Oct 2006). Kinetics of elimination of urinary metabolites of acrylamide in humans. Toxicological Sciences, 93 (2):256-267.

Dybing, E., Farmer, P.B., Andersen, M., Fennell, T.R., Lalljle, S.P.D., Muller, D.J.G., Olin, S., Peterson, B.J., Schlatter, J., Scholz, G., Scimeca, J.A., Slimani, N., Tornqvist, M., Tuijtelaars, S., & Verger, P. (2005). Human exposure and internal dose assessments of acrylamide in food. Food and Chemical Toxicology, 43 (3):365-410.

Fennell, T.R., Sumner, S.C.J., Snyder, R.W., Burgess, J., Spicer, R., Bridson, W.E., & Friedman, M.A. (2005). Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicological Sciences, 85 (1):447-459.

Fennell, T.R. (2004). Comparison of acrylamide metabolism in humans and rodents. Abstracts of Papers of the American Chemical Society, 227:U40-U40.

Fennell, T.R., Krol, W.L., Sumner, S.C.J., & Snyder, R.W. (2004). Pharmacokinetics of dibutylphthalate in pregnant rats. Toxicological Sciences, 82 (2):407-418.

Fennell, T.R., Snyder, R.W., Parkinson, C., & James, R.A. (2004). The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome P450 in Fischer rats. Toxicological Sciences, 81 (1):7-13.

Sumner, S.C.J., Williams, C.C., Snyder, R.W., Krol, W.L., Asgharian, B., & Fennell, T.R. (2003). Acrylamide: A comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure. Toxicological Sciences, 75:260-270.

Sumner, S.C.J., Janszen, D.B., Asgharian, B., Moore, T.A., Bobbitt, C.M., & Fennell, T.R. (2003). Blood pharmacokinetics of tertiary amyl methyl ether in male and female F344 rats and CD-1 mice after nose-only inhalation exposure. Journal of Applied Toxicology, 23:419-425.

Sumner, S.C.J., Asgharian, B., Moore, T.A., Parkinson, H.D., Bobbitt, C.M., & Fennell, T.R. (2003). Characterization of metabolites and disposition of tertiary amyl methyl ether in male F344 rats following inhalation exposure. Journal of Applied Toxicology, 23:411-417.

Fennell, T.R., Snyder, R.W., Krol, W.L., & Sumner, S.C. (2003). Comparison of the hemoglobin adducts formed by administration of N-methylolacrylamide and acrylamide to rats. Toxicological Sciences, 71 (2):164-175.

View all publications by Timothy R. Fennell…