Rochelle W. Tyl

Expertise

Regulatory Toxicology
Developmental and Reproductive Toxicology
Endocrine Toxicology
Developmental Neurotoxicology

Biography

Rochelle W. Tyl, PhD, DABT, Distinguished Fellow, developmental and reproductive toxicology, appointed in October 2008, has more than 40 years of experience in developmental and reproductive biology and toxicology. Dr. Tyl was named an RTI Senior Fellow in 2005. She is the research director of Life Sciences and Toxicology at RTI. Tyl has been study director for more than 30 multi-generation studies, more than 20 specialized reproductive and endocrine toxicity studies, and more than 155 developmental toxicity studies. Her research on bisphenol A (BPA) received international recognition when the World Health Organization and the European Union used her study results to perform formal risk assessments for this chemical. Tyl lectures nationally and internationally by invitation and has participated in multiple federal agency workgroups. She is the author or coauthor of more than 90 peer-reviewed articles, 18 book chapters, more than 85 abstracts, and more than 38 government reports. Tyl was president of the Teratology Society for 2003-2004 and president of the reproductive and developmental toxicology specialty section of the Society of Toxicology for 2007-2008. Since 1983, she has been a diplomate of the American Board of Toxicology and served on the ABT Board of Directors (2003-2007).

Education

PhD, Developmental Genetics, University of Connecticut, Storrs; BA (cum laude), Biological Science, University of Connecticut, Storrs.

Selected Publications

Tyl, R.W., Myers, C.B., Marr, M.C., Sloan, C.S., Castillo, N.P., Veselica, M.M., Seely, J.C., Dimond, S.S., Van Miller, J.P., Shiotsuka, R.N., Beyer, D., Hentges, S.G., & Waechter, J.M. (Aug 2008). Two-generation reproductive toxicity study of dietary bisphenol A (BPA) in CD-1 (Swiss) mice. Toxicological Sciences, 104 (2):362-384.

Tyl, R.W., Crofton, K., Moretto, A., Moser, V., Sheets, L.P., & Sobotka, T.J. (2008 Jul). Identification and interpretation of developmental neurotoxicity effects: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicology and Teratology , 30 (4):349-381.

Tyl, R.W., Myers, C.B., Marr, M.C., Sloan, C.S., Castillo, N.P., Veselica, M.M., Seely, J.C., Dimond, S.S., Van Miller, J.P., Shiotsuka, R.S., Stropp, G.D., Waechter, J.M., & Hentges, S.G. (Apr 2008). Two-generation reproductive toxicity evaluation of dietary 17beta-estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) mice. Toxicological Sciences, 102 (2):392-412.

Tyl, R.W., Myers, C.B., Marr, M.C., Castillo, N.P., Veselica, M.M., Joiner, R.L., Dimond, S.S., Van Miller, J.P., Stropp, G.D., Waechter, J.M., & Hentges, S.G. (2008 Feb). One-generation reproductive toxicity study of dietary 17beta-estradiol (E2; CAS No. 50-28-2) in CD-1((R)) (Swiss) mice. Reproductive Toxicology, 25 (2):144-160.

Tyl, R.W., Chernoff, N., & Rogers, J.M. (2007 Dec). Altered axial skeletal development. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 80 (6):451-472.

Zoeller, R.T., Tyl, R.W., & Tan, S.W. (Jan 2007). Current and Potential Rodent Screens and Tests for Thyroid Toxicants. Critical Reviews in Toxicology, 37 (1 & 2):55-95.

Zoeller, R.T., Tan, S.W., & Tyl, R.W. (Jan 2007). General Background on the Hypothalamic-Pituitary-Thyroid (HPT) Axis. Critical Reviews in Toxicology, 37 (1 & 2):11-53.

Tyl, R.W., & Marr, M.C. (2006). Developmental toxicity testing - Methodology (Chapter 7). In R.D. Hood (Ed.), Developmental and Reproductive Toxicology: A Practical Approach, 2nd edition. Boca Raton, FL: CRC Press.

Slikker, Jr., W., Acuff, K., Boyd, W., Chelonis, J., Crofton, K.M., Dearlove, G., Li, A., Moser, V., Newland, C., Rossi, J., Schantz, S., Sette, W., Stanford, M., Tyl, R.W., & Sobotka, T. (2005). Behavioral test methods workshop. Neurotoxicology and Teratology , 27 (3):417-427.

Tyl, R.W., Price, C.J., Marr, M.C., Myers, C.B., van Birgelen, A.P.J.M., & Jahnke, G.D. (2003). Developmental Toxicity Evaluation of Sodium Thioglycolate Administered Topically to Sprague-Dawley (CD) Rats and New Zealand White Rabbits. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 68:144-161.

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