James M. Mathews

Expertise

Drug Metabolism
Pharmacokinetics

Biography

James Mathews, PhD, has over 20 years of experience in directing investigations of the metabolism and disposition of drugs, commodity chemicals, and crop protection products for industry, regulatory agencies, and the National Institutes of Health. In 1985, Dr. Mathews joined RTI as a study director responsible for ADME investigations of xenobiotics in mammals. While at RTI, he has overseen the development of a full-service DMPK department, conducting investigations focused from the molecular and biomolecular level through cellular and subcellular investigations, and studies with isolated organs and in vivo models. He is currently the director of RTI's Drug Metabolism and Pharmacokinetics department. In addition to authoring 40 peer-reviewed articles, Dr. Mathews is a diplomate of the American Board of Toxicology and a member of the organizing committees and session chair for meetings of the International Society for the Study of Xenobiotics and the Gordon Conference on Drug Metabolism. Dr. Mathews has an adjunct faculty appointment with the School of Pharmacy at the University of North Carolina, Chapel Hill.

Education

PhD, Pharmaceutical Chemistry, University of California, San Francisco; BS, Chemistry, California State University, Northridge.

Selected Publications

Etheridge, A.S., Black, S.R., Patel, P.R., So, J., & Mathews, J.M. (July 2007). An in vitro evaluation of cytochrome P450 inhibition and p-glycoprotein interaction with goldenseal, ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Medica, 73 (9):731-741.

Black, S.R., Decosta, K.S., Patel, P.R., & Mathews, J.M. (April 2007). [14C]bis(2-chloroethoxy)methane: Comparative absorption, distribution, metabolism and excretion in rats and mice. Xenobiotica, 37 (4):427-440.

Garner, C.E., Sumner, S.C., Davis, J.G., Burgess, J.P., Yueh, Y., Demeter, J., Zhan, Q., Valentine, J., Jeffcoat, A.R., Burka, L.T., & Mathews, J.M. (Aug 2006). Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration. Toxicology and Applied Pharmacology, 215 (1):23-36.

Mathews, J.M., Etheridge, A.S., Valentine, J.L., Black, S.R., Coleman, D.P., Patel, P.R., So, J., & Burka, L.T. (2005). Pharmacokinetics and disposition of the kavalactone kawain: Interaction with kava extract and kavalactones in vivo and in vitro. Drug Metabolism and Disposition, 33 (10):1555-1563.

Mathews, J.M., Etheridge, A.S., & Black, S.R. (2002). Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metabolism and Disposition, 30 (11):1153-1157.

deCosta, K., Black, S.R., Thomas, B.F., Burgess, J.P., & Mathews, J.M. (2001). Metabolism and disposition of alpha-methylstyrene in rats. Drug Metabolism and Disposition, 29 (2):166-171.

Kadiiska, M.B., deCosta, K., Mason, R.P., & Mathews, J.M. (2000). Reduction of 1,3-diphenyl-1-triazene by rat hepatic microsomes, by cecal microflora, and in rats generates the phenyl radical metabolite: An ESR spin-trapping investigation. Chemical Research in Toxicology, 13 (11):1082-1086.

Mathews, J.M., & deCosta, K. (1999). Absorption, metabolism, and disposition of 1,3-diphenyl-1- triazene in rats and mice after oral, IV, and dermal administration. Drug Metabolism and Disposition, 27 (12):1499-1504.

Mathews, J.M., Etheridge, A.S., Raymer, J.H., Black, S.R., Pulliam, D.W., & Bucher, J.R. (1998). Selective inhibition of cytochrome P450 2E1 in vivo and in vitro with trans-1,2-dichloroethylene. Chemical Research in Toxicology, 11 (7):778-785.

Mathews, J.M., Garner, C.E., & Matthews, H.B. (1995 Jul). Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chemical Research in Toxicology, 8 (5):625-633.

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