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Irma M. Grossi

Expertise

Preclinical Drug Development
Metastasis Models
Eicosanoid Metabolism
Integrins and Cell Adhesion

Biography

Irma "Gina" Grossi, PhD, joined RTI in 2005 as senior director of life sciences and toxicology. Dr. Grossi has extensive experience in drug safety and evaluation, joining RTI after eight years in a variety of high-level research positions at Battelle Memorial Institute. Most recently, she served as manager of commercial toxicology and senior program director for Battelle’s multimillion dollar per year toxicology division. Dr. Grossi is well-known in the toxicology field, having authored or coauthored eight book chapters and numerous peer-reviewed journal articles and abstracts. She is a frequent speaker at seminars around the world on topics such as drug development, cancer metastasis, and the effect of virus infection on brain function. Dr. Grossi is a member of the Society of Toxicology, American Association for the Advancement of Science, Women in Cancer Research, and American College of Toxicology.

Education

PhD, Cancer Biology, School of Medicine, Wayne State University; MBA Certificate, Fischer School of Business, Ohio State University; Graduate Studies, Biochemistry/Molecular Biology, University of Nebraska; BS, Biological Sciences, Central Michigan University.

Selected Publications

Li, M., Wang, H., Hill, D.L., Stinson, S., Veley, K., Grossi, I., Peggins, J., Covey, J.M., & Zhang, R. (2005 Dec 6). Preclinical pharmacology of the novel antitumor agent adaphostin, a tyrphostin analog that inhibits bcr/abl. Cancer Chemotherapy and Pharmacology, 57 (5):607-614.

Parise, R.A., Sparrow, B.R., Merrill, J.W., Grossi, I.M., Covey, J.M., Peggins, J.O., & Egorin, M.J. (2004 Oct 15). Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of halofuginone in plasma. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 810 (1):35-40.

Dahl, A.R., Grossi, I.M., Houchens, D.P., Scovell, L.J., Placke, M.E., Imondi, A.R., Stoner, G.D., De Luca, L.M., Wang, D., & Mulshine, J.L. (2000 Aug). Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clinical Cancer Research, 6 (8):3015-3024.

Honn, K.V., Tang, D.G., Grossi, I., Duniec, Z.M., Timar, J., Renaud, C., Leithauser, M., Blair, I., Johnson, C.R., & Diglio, C.A. (1994 Jan 15). Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction. Cancer Research, 54 (2):565-574.

Honn, K.V., Tang, D.G., Grossi, I.M., Renaud, C., Duniec, Z.M., Johnson, C.R., & Diglio, C.A. (1994 Jan). Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis. Experimental Cell Research, 210 (1):1-9.

Chen, Y.Q., Gao, X., Timar, J., Tang, D., Grossi, I.M., Chelladurai, M., Kunicki, T.J., Fligiel, S.E., Taylor, J.D., & Honn, K.V. (1992 Aug 25). Identification of the alpha IIb beta 3 integrin in murine tumor cells. Journal of Biological Chemistry, 267 (24):17314-17320.

Honn, K.V., Grossi, I.M., Diglio, C.A., Wojtukiewicz, M., & Taylor, J.D. (1989 Sep). Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)-HETE-induced endothelial cell retraction. Faseb Journal, 3 (11):2285-2293.

Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., Nelson, K.K., Diglio, C.A., Taylor, J.D., & Honn, K.V. (1989 Feb 15). Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Research, 49 (4):1029-1037.

Grossi, I.M., Hatfield, J.S., Fitzgerald, L.A., Newcombe, M., Taylor, J.D., & Honn, K.V. (1988 May). Role of tumor cell glycoproteins immunologically related to glycoproteins Ib and IIb/IIIa in tumor cell-platelet and tumor cell-matrix interactions. Faseb Journal, 2 (8):2385-2395.

Grossi, I.M., Fitzgerald, L.A., Kendall, A., Taylor, J.D., Sloane, B.F., & Honn, K.V. (1987 Dec). Inhibition of human tumor cell induced platelet aggregation by antibodies to platelet glycoproteins Ib and IIb/IIIa. Proceedings of the Society for Experimental Biology and Medicine, 186 (3):378-383.

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