Susan J. Sumner

Expertise

Biomarkers
Exposure Assessment
Metabolomics
Predictive Toxicology

Biography

Susan Sumner, PhD, has more than 15 years of experience in mechanistic-based research, specializing in the areas of metabolism and metabolomics. Dr. Sumner has served as a principal investigator and GLP study director, conducting studies to evaluate pharmacokinetics, ADME (absorption, distribution, metabolism, and excretion), and toxicity of compounds. Her early career activities at the CIIT Centers for Health Research (1989-2002) led to the development of an NMR approach to characterize and quantify metabolites in urine from rodents and humans following controlled exposure to carbon-13-labeled compounds. She is experienced with the development of IRB protocols for volunteer exposures to environmental and pharmaceutical agents, providing guidance in study design and sample collection for compliance with analytical measurements. Dr. Sumner joined RTI in 2004 as a senior metabolism scientist, where she immediately integrated an RTI-wide metabolomics effort and developed a scientific plan to study mechanisms of idiosyncratic drug-induced liver injury.

Education

PhD, Physical Chemistry, North Carolina State University; BS, Chemistry (Biology minor), North Carolina State University.

Selected Publications

Garner, C.E., Sumner, S.C., Davis, J.G., Burgess, J.P., Yueh, Y., Demeter, J., Zhan, Q., Valentine, J., Jeffcoat, A.R., Burka, L.T., & Mathews, J.M. (Aug 2006). Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration. Toxicology and Applied Pharmacology, 215 (1):23-36.

Fennell, T.R., Sumner, S.C.J., Snyder, R.W., Burgess, J., Spicer, R., Bridson, W.E., & Friedman, M.A. (2005). Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicological Sciences, 85 (1):447-459.

Weis, B.K., Balshawl, D., Barr, J.R., Brown, D., Ellisman, M., Liov, P., Omenn, G., Potter, J.D., Smith, M.T., Sohn, L., Suk, W.A., Sumner, S., Swenberg, J., Walt, D.R., Watkins, S., Thompson, C., & Wilson, S.H. (2005). Personalized exposure assessment: Promising approaches for human environmental health research. Environmental Health Perspectives, 113 (7):840-848.

Fennell, T.R., Krol, W.L., Sumner, S.C.J., & Snyder, R.W. (2004). Pharmacokinetics of dibutylphthalate in pregnant rats. Toxicological Sciences, 82 (2):407-418.

Sumner, S.C.J., Williams, C.C., Snyder, R.W., Krol, W.L., Asgharian, B., & Fennell, T.R. (2003). Acrylamide: A comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure. Toxicological Sciences, 75:260-270.

Sumner, S.C.J., Janszen, D.B., Asgharian, B., Moore, T.A., Bobbitt, C.M., & Fennell, T.R. (2003). Blood pharmacokinetics of tertiary amyl methyl ether in male and female F344 rats and CD-1 mice after nose-only inhalation exposure. Journal of Applied Toxicology, 23:419-425.

Sumner, S.C.J., Asgharian, B., Moore, T.A., Parkinson, H.D., Bobbitt, C.M., & Fennell, T.R. (2003). Characterization of metabolites and disposition of tertiary amyl methyl ether in male F344 rats following inhalation exposure. Journal of Applied Toxicology, 23:411-417.

Fennell, T.R., Snyder, R.W., Krol, W.L., & Sumner, S.C. (2003). Comparison of the hemoglobin adducts formed by administration of N-methylolacrylamide and acrylamide to rats. Toxicological Sciences, 71 (2):164-175.

Sumner, S.C.J., Janszen, D.B., Asgharian, B., Moore, T.A., Parkinson, H.D., & Fennell, T.R. (2003). Species and gender differences in the metabolism and distribution of tertiary amyl methyl ether in male and female rats and mice after inhalation exposure or gavage administration. Journal of Applied Toxicology, 23:427-436.

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